Philipp Wahle of the lab of Robert Zinzen developed a highly resolved virtual model of a fly embryo, which shows which genes are active in which cell. He received the MDC PhD Prize at the annual Graduate Ceremony on November 24, 2017 for the paper in which he published these results. Two second-place publications were awarded […]
In a technological tour de force, Berlin scientists have created a virtual model of an early fly embryo. Its interactive interface allows researchers to explore the blueprint that underlies development at unprecedented spatial resolution and predict which cells express which genes.
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
A group of scientists in Israel and Germany, led by Prof. Sebastian Kadener from the Hebrew University of Jerusalem, have discovered a protein-encoding function for circular RNA. This kind of RNA molecule is highly active in brain cells and could play an important role in neurodegenerative diseases.
The 3D landscapes of the genome have to change all the time. Otherwise genes would not be expressed properly and physiology would be in disarray. Ana Pombo’s group is mapping this genomic regulation.
Cells have to pack their genetic material into the tiny nucleus. This creates spatial interactions between genes and their switches, which can affect human health and disease. A new technique ‘maps’ this three-dimensional geography of the genome.
Pupils participating in the MINT Excellence Academy in “Systems Biology” visited the MDC this week. Twenty pupils have catched a glimpse of how researchers combine laboratory and computational science.
If one looks beyond individual molecules, biology quickly becomes complex. Computer scientist Uwe Ohler are using algorithms and mathematical models to map a path through this tangle of dependencies.
Scientists have uncovered details of the cellular mechanisms that control the direct programming of stem cells into motor neurons. The scientists analyzed changes that occur in the cells over the course of the reprogramming process.
Some proteins behave in an unusual way: the older they become, the more stable they are. This is what Erik McShane found out, this year’s winner of the annual PhD Prize Award.