Oliver Daumke’s lab figures out how the inner membranes of mitochondria “get their groove” and assume the complex shapes they need to carry out crucial cellular functions
Oliver Daumke’s lab figures out how the inner membranes of mitochondria “get their groove” and assume the complex shapes they need to carry out crucial cellular functions.
Cats are not allowed in the lab of Oliver Daumke’s research team. Yet they make a valuable contribution to research – and we reveal what that is …
Small “bubbles” frequently form on membranes of cells and are taken up into their interior. The process involves EHD proteins – a focus of research by Oliver Daumke of the MDC. He and his team have now shed light on how these proteins assemble on the surface of a cell and reshape its membrane.
“Ideally as a postdoc you should aim to publish as last as well as first author and gather experience writing grants,” says Professor Yves Muller. The crystallographer emphasises that postdocs wanting to become group leads need to enjoy independence and be ready to follow their own ideas.
Some anticancer agents intend to disturb the function of the p97 protein complex, which is essential for survival of cancer cells. A team of researchers of the MDC has now found a way to break up the p97 complex into its subunits.
MDC structural biologist Prof. Udo Heinemann is much in demand; with his research activities and expertise he enjoys an outstanding international reputation. So it comes as no surprise that he has now been elected onto one of the Review Boards at the Deutsche Forschungsgemeinschaft (DFG). As a scientist, he is primarily interested in the crystallisation […]
A common method of obtaining three-dimensional structures of proteins (such as the viral molecule described in the Daumke story) requires that a huge number of copies arrange themselves in tight arrays. They are then exposed to a high-intensity X-ray beam, producing a pattern that can be analyzed to produce an image of the structure of […]
There is no treatment for infection with the dangerous hantavirus. Scientists at the Max Delbrück Center for Molecular Medicine (MDC) have now identified the three-dimensional structure of a hantavirus protein that is essential for replication of the virus. They have published their findings in the journal Cell Reports, providing a blueprint for the design of […]
Researchers in Berlin and Hannover have published a new structure of the protein dynamin in the journal Nature. The structure reveals how dynamin building blocks can form larger assemblies. It also shows how mutations that cause certain genetic diseases disrupt dynamin regulation. Many molecules can’t cross cell membranes without the help of vesicles – bubbles […]