Structural Biology

Udo Heinemann: Structural biology helps us ask the right scientific questions

MDC structural biologist Prof. Udo Heinemann is much in demand; with his research activities and expertise he enjoys an outstanding international reputation. So it comes as no surprise that he has now been elected onto one of the Review Boards at the Deutsche Forschungsgemeinschaft (DFG). As a scientist, he is primarily interested in the crystallisation […]

Cartoon: The sorriest excuse for a protein crystal

A common method of obtaining three-dimensional structures of proteins (such as the viral molecule described in the Daumke story) requires that a huge number of copies arrange themselves in tight arrays. They are then exposed to a high-intensity X-ray beam, producing a pattern that can be analyzed to produce an image of the structure of […]

Structure of a hantavirus protein as a promising model for drug design

There is no treatment for infection with the dangerous hantavirus. Scientists at the Max Delbrück Center for Molecular Medicine (MDC) have now identified the three-dimensional structure of a hantavirus protein that is essential for replication of the virus. They have published their findings in the journal Cell Reports, providing a blueprint for the design of […]

Bent to the task: New dynamin structure reveals how it wraps around membranes

Researchers in Berlin and Hannover have published a new structure of the protein dynamin in the journal Nature. The structure reveals how dynamin building blocks can form larger assemblies. It also shows how mutations that cause certain genetic diseases disrupt dynamin regulation. Many molecules can’t cross cell membranes without the help of vesicles – bubbles […]