The Landthaler lab at the MDC and their collaborators discover that a herpes virus triggers the production of over 1,000 “antisense” transcripts in the genomes of cells it infects – hinting at a new mechanism by which viruses overcome cellular defenses.
RNA Biology @en
Where proteins are localized within a cell is crucial to their proper function, especially in cells like neurons. It affects neuronal development and even learning and memory. A research team led by Marina Chekulaeva has for the first time systematically analyzed how this localization comes about. Their article appeared in Nature Communications.
With April 1st, systems biologist Markus Landthaler of the MDC has been appointed Professor for “RNA Systems Biology” at the Humboldt-Universität zu Berlin.
A group of scientists in Israel and Germany, led by Prof. Sebastian Kadener from the Hebrew University of Jerusalem, have discovered a protein-encoding function for circular RNA. This kind of RNA molecule is highly active in brain cells and could play an important role in neurodegenerative diseases.
Venturing into one of the new big topics in RNA biology, the circRTrain network of eight scientific experts from Europe and Israel will be coordinated by Nikolaus Rajewsky.
Evolution has produced quality control systems that permit our cells to detect and destroy defective messenger RNAs before they go on to produce faulty proteins. Markus Landthaler’s group has now discovered how a protein called an RNA helicase helps process RNAs so that they can be destroyed or recycled. The work appeared in the May […]