Press Release

Genome editing: efficient CRISPR experiments in mouse cells

The new program “CrispRGold” program helps scientists to identify the most effective and specific RNA sequences for use genome editing experiments. It has been devised by a group of researchers headed by Prof. Klaus Rajewsky and is now described in the journal PNAS. The team has also developed a new mouse model that already carries the Cas9 protein.

A naked mole-rat in the lab. Image: Laura-Nadine Schuhmacher, Cambridge University.

How the naked mole-rat escapes inflammatory pain

In injuries and inflammation, naked mole-rats do not develop normal hypersensitivity to temperature stimuli. This is due to a tiny change in a receptor molecule on cells called TrkA, as a research team from the MDC has now discovered. The work, which appears in the journal Cell Reports, may be important for pain therapy in humans.

The life cycle of proteins

Some proteins behave in an unusual way: the older they become, the more stable they are. A research team at the MDC has now published this surprising finding in the journal Cell. Their work has traced the life cycle of thousands of proteins from synthesis to disposal. The results are relevant for diseases where there are surplus copies of certain genes.

The life cycle of proteins

Some proteins behave in an unusual way: the older they become, the more stable they are. A research team at the MDC has now published this surprising finding in the journal Cell. Their work has traced the life cycle of thousands of proteins from synthesis to disposal. The results are relevant for diseases where there are surplus copies of certain genes.

Why tumors evade immunotherapy

Immunotherapy is a new and highly promising form of treatment for cancer. In many patients, however, tumors recur after immunotherapy. In the latest issue of the Journal of Experimental Medicine, the members of a research team from the MDC, the BIH, and the Charité explain why some tumors recur and how this can be prevented. The findings will aid the selection of suitable target points for immunotherapy.