Metabolic Disease

A protein in the brain links body weight, metabolism and activity

For many obese people gaining weight is a vicious cycle. Scientists at the MDC have now uncovered a contributing factor: genetic variants linked to obesity cause the brain to produce too much of a protein called Cadm1. The result is a disruption in the regulation of body weight and changes in behavior and metabolism, as reported by Matthew Poy and his colleagues in Nature Neuroscience.

Fat cells with insulin receptor marked red and lipid droplets marked white.

Insulin-sensitive fat leads to obesity

SORLA is a protein that influences metabolism in adipose tissue. If there is too much of the molecule, fat cells become overly sensitive to insulin and break down less fat. This new link between SORLA and increases in body weight was discovered by MDC researchers. SORLA was previously known for its role in defending the brain against Alzheimer’s disease.

Tape measure vs. body scanner: study investigates relationship between abdominal volume and metabolic state

Abdominal fat in overweight patients is a key indicator for metabolic syndrome (MetS). MetSScan, a new health study by the Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association, intends to find out whether metabolic state can be predicted more reliably using 3D scanners rather than traditional methods. The study, which is still […]