When we drink little, we produce less urine. But how is this process regulated? An international team of scientists led by Prof. Kai Schmidt-Ott of the Max Delbrück Center for Molecular Medicine (MDC) has now shed light on how the kidneys concentrate urine.
For many obese people gaining weight is a vicious cycle. Scientists at the MDC have now uncovered a contributing factor: genetic variants linked to obesity cause the brain to produce too much of a protein called Cadm1. The result is a disruption in the regulation of body weight and changes in behavior and metabolism, as reported by Matthew Poy and his colleagues in Nature Neuroscience.
When oxygen gets scarce, the naked mole-rat throws a metabolic switch to draw energy from fructose rather than glucose.
When oxygen runs low in their underground burrows, naked mole rats have a unique method of survival. Their metabolism switches from a glucose-based system, which depends on oxygen, to one that makes use of fructose. For a while this suffices to protect sensitive organs such as the heart and brain.
Thomas Willnow analyzes the connections between metabolism and dementia. We asked him why European funding is essential to his research and why he considers it to be risky.
Francesca Spagnoli’s team reprogrammed cells from the liver of mice to become precursor cells of the pancreas by altering a single gene. The results could help diabetics in the future.
The Berlin-Nord Study Centre has now recruited half of the 10,000 volunteers for Germany’s largest ever cohort study, the NAKO Health Study. It serves the improvement of prevention, early detection and treatment of widespread diseases.
SORLA is a protein that influences metabolism in adipose tissue. If there is too much of the molecule, fat cells become overly sensitive to insulin and break down less fat. This new link between SORLA and increases in body weight was discovered by MDC researchers. SORLA was previously known for its role in defending the brain against Alzheimer’s disease.
SORLA is a protein that influences the balance of metabolic processes in adipose tissue, a particular form of fat. Too much of it makes fat cells overly sensitive to insulin, which leads them to break down less fat. SORLA was previously known for its protective role in Alzheimer’s disease.
Abdominal fat in overweight patients is a key indicator for metabolic syndrome (MetS). MetSScan, a new health study by the Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association, intends to find out whether metabolic state can be predicted more reliably using 3D scanners rather than traditional methods. The study, which is still […]