Genetics

Study provides more clarity on the genetic causes of children’s food allergies

What role do genes play in egg, milk, and nut allergies? A study published in Nature Communications, led by the Max Delbrück Center for Molecular Medicine (MDC) and Charité – Universitätsmedizin Berlin, has found five genetic risk loci that point to the importance of skin and mucous membrane barriers and the immune system in the development of food allergies.

Changing Architecture: A new understanding of the spatial organization of our genome

It has now been 15 years since scientists celebrated the completion of the human genome. At that point, scientists had determined the entire sequence of the genetic letters making up our DNA. It is now known that this was only an initial step in a long journey: in addition to the chemical letters, information is […]

How to translocate genes, prominent scientists, and some really big fish

On November 2, Fred Alt, Professor of Pediatrics and Genetics at Harvard University, spoke to a full house in the Axon as the first speaker in a new seminar series called the MDC Lectures. The series, coordinated by former Scientific Director Walter Birchmeier, was the brainchild of the Extended Directorate, and will host one high-ranking […]

Genetic cause of cleft palate

Some children are born with cleft palates and, of those children, some have an asymmetrical face and a malformed ear. A team of scientists led by Berlin-based researcher Enno Klußmann of the Max Delbrück Center for Molecular Medicine (MDC) has taken an important step towards discovering the genetic causes of this condition, known as Goldenhar […]

Perfecting the tools to rewrite genomes

For many years, scientists have dreamed of manipulating DNA the way copy-editors change texts: from replacing single letters of the genetic code to altering sequences of any length and adding, deleting, replacing, or rearranging large regions of chromosomes. Changes of all of these types have occurred naturally over the course of evolution, and they even […]