Epigenetics & Gene Regulation

Changing Architecture: A new understanding of the spatial organization of our genome

It has now been 15 years since scientists celebrated the completion of the human genome. At that point, scientists had determined the entire sequence of the genetic letters making up our DNA. It is now known that this was only an initial step in a long journey: in addition to the chemical letters, information is […]

Watching the ribosome at work

A new statistical method could help to clarify the function of unknown genes. A research team under Uwe Ohler of the Berlin Institute for Medical Systems Biology (BIMSB) at the Max Delbrück Center for Molecular Medicine (MDC) has adapted and tested a filter method from speech signal processing that makes sequencing data more interpretable. First […]

How to translocate genes, prominent scientists, and some really big fish

On November 2, Fred Alt, Professor of Pediatrics and Genetics at Harvard University, spoke to a full house in the Axon as the first speaker in a new seminar series called the MDC Lectures. The series, coordinated by former Scientific Director Walter Birchmeier, was the brainchild of the Extended Directorate, and will host one high-ranking […]

New level of gene regulation plays a role in cardiovascular diseases

When genes are read at the wrong time or in the wrong place they can cause a disease. Less well known is the extent to which the following step, the translation of the gene transcripts into proteins, is also prone to errors. Now, a team lead by Prof. Norbert Hübner of the MDC in Berlin-Buch […]

From sequencing DNA to sequencing life

Whoever invented the term Next-Generation Sequencing (NGS) wasn’t making things easy for whoever has to name its successor – what would you call the next next generation of sequencing technology? The field continues to develop at a rapid pace, says Wei Chen, who heads the Genomics platform at the Berlin Institute for Medical Systems Biology (BIMSB). […]

Comprehensive new map helps understanding of gene regulation by microRNAs

All the cells in our bodies, be they nerve or kidney cells, blood or skin cells, carry the same genetic information. And yet they all differ considerably. This is because different genes are transcribed in each cell type. In recent years, scientists have found a new class of molecules, so-called “microRNAs,” that play a crucial […]