When we drink little, we produce less urine. But how is this process regulated? An international team of scientists led by Prof. Kai Schmidt-Ott of the Max Delbrück Center for Molecular Medicine (MDC) has now shed light on how the kidneys concentrate urine.
Epigenetics & Gene Regulation
Ana Pombo’s lab discovers a mechanism that silences genes but keeps them continually poised for action – even though they may never be used.
Scientists of the International Human Epigenome Consortium released a collection of 41 publications in high-impact journals. MDC group leader Prof. Nikolaus Rajewsky contributed as a researcher and member of the German Epigenome Program.
It has now been 15 years since scientists celebrated the completion of the human genome. At that point, scientists had determined the entire sequence of the genetic letters making up our DNA. It is now known that this was only an initial step in a long journey: in addition to the chemical letters, information is […]
A new statistical method could help to clarify the function of unknown genes. A research team under Uwe Ohler of the Berlin Institute for Medical Systems Biology (BIMSB) at the Max Delbrück Center for Molecular Medicine (MDC) has adapted and tested a filter method from speech signal processing that makes sequencing data more interpretable. First […]
On November 2, Fred Alt, Professor of Pediatrics and Genetics at Harvard University, spoke to a full house in the Axon as the first speaker in a new seminar series called the MDC Lectures. The series, coordinated by former Scientific Director Walter Birchmeier, was the brainchild of the Extended Directorate, and will host one high-ranking […]
While progress has surely been made in recent years, we all know that there remain some important barriers to full gender equality in science and many other fields. It’s not enough to change minds alone: traces of old habits linger in educational systems and institutions. The best way to expose gender issues – which are […]
When genes are read at the wrong time or in the wrong place they can cause a disease. Less well known is the extent to which the following step, the translation of the gene transcripts into proteins, is also prone to errors. Now, a team lead by Prof. Norbert Hübner of the MDC in Berlin-Buch […]
Whoever invented the term Next-Generation Sequencing (NGS) wasn’t making things easy for whoever has to name its successor – what would you call the next next generation of sequencing technology? The field continues to develop at a rapid pace, says Wei Chen, who heads the Genomics platform at the Berlin Institute for Medical Systems Biology (BIMSB). […]
All the cells in our bodies, be they nerve or kidney cells, blood or skin cells, carry the same genetic information. And yet they all differ considerably. This is because different genes are transcribed in each cell type. In recent years, scientists have found a new class of molecules, so-called “microRNAs,” that play a crucial […]