Researchers at the MDC have developed antibodies that promise to heal multiple myeloma. The biotechnology company Heidelberg Pharma will now develop one of these antibodies to an antibody-toxin agent and test it clinically at the end of 2018.
If one looks beyond individual molecules, biology quickly becomes complex. Computer scientist Uwe Ohler are using algorithms and mathematical models to map a path through this tangle of dependencies.
Slightest touch can evoke pain in patients suffering from nerve injuries. Researchers of the MDC now have suppressed this type of neuropathic pain in mice by applying a chemical substance to the skin. The method could work in humans.
Scientists have uncovered details of the cellular mechanisms that control the direct programming of stem cells into motor neurons. The scientists analyzed changes that occur in the cells over the course of the reprogramming process.
A new study has discovered that gene mutations in a protein called titin affect the heart function in healthy individuals. It was previously thought that the mutations affect only patients with dilated cardiomyopathy, one of the most common forms of inherited heart disease.
Dr. Matthias Leisegang is the recipient of this year’s Curt Meyer Memorial Prize for his research work into analysing cancer mutations as a target in adoptive T-cell therapy. His work will allow the development of a patient-specific immunotherapy that fights cancer in a targeted way.
Dr. Roland F. Schwarz of the MDC conducts research on tumors using bioinformatics. He has just been awarded the Prize of the Berlin-Brandenburg Academy of Sciences and Humanities (BBAW), donated by the Monika Kutzner Foundation for the Advancement of Cancer Research, for his outstanding work.
Protein Kinase A (PKA) is a protein that enjoys enough fame to be sketched by young biochemists listening to lectures about how it is regulated. The fundamental kinase is present throughout the body with a role in countless processes. It’s easy to think PKA is so well studied that we know everything about it, but scientists at the MDC have found a new layer of PKA regulation which was published this week in Nature Communications.
In injuries and inflammation, naked mole-rats do not develop normal hypersensitivity to temperature stimuli. This is due to a tiny change in a receptor molecule on cells called TrkA, as a research team from the MDC has now discovered. The work, which appears in the journal Cell Reports, may be important for pain therapy in humans.
Some proteins behave in an unusual way: the older they become, the more stable they are. A research team at the MDC has now published this surprising finding in the journal Cell. Their work has traced the life cycle of thousands of proteins from synthesis to disposal. The results are relevant for diseases where there are surplus copies of certain genes.