Disease Research

Prof. Dr. Clemens A. Schmitt (Member of the Board of the Berlin Cancer Society), Prof. Dr. Petra Feyer (Chairman of the Board of the Berlin Cancer Society), Dr. Matthias Leisegang (Charité), Dr. Kristina Zappel (Managing Director of the Berlin Cancer Society). Image: Konstantin Gastmann.

Curt Meyer Memorial Prize awarded to Charité scientist – Commendation for tumor immunologist Matthias Leisegang

Dr. Matthias Leisegang is the recipient of this year’s Curt Meyer Memorial Prize for his research work into analysing cancer mutations as a target in adoptive T-cell therapy. His work will allow the development of a patient-specific immunotherapy that fights cancer in a targeted way.

MDC cancer researcher Roland Schwarz awarded BBAW prize

Dr. Roland F. Schwarz of the MDC conducts research on tumors using bioinformatics. He has just been awarded the Prize of the Berlin-Brandenburg Academy of Sciences and Humanities (BBAW), donated by the Monika Kutzner Foundation for the Advancement of Cancer Research, for his outstanding work.

New brick in PKA Legoland adds complexity to a picture we thought we knew well

Protein Kinase A (PKA) is a protein that enjoys enough fame to be sketched by young biochemists listening to lectures about how it is regulated. The fundamental kinase is present throughout the body with a role in countless processes. It’s easy to think PKA is so well studied that we know everything about it, but scientists at the MDC have found a new layer of PKA regulation which was published this week in Nature Communications.

A naked mole-rat in the lab. Image: Laura-Nadine Schuhmacher, Cambridge University.

How the naked mole-rat escapes inflammatory pain

In injuries and inflammation, naked mole-rats do not develop normal hypersensitivity to temperature stimuli. This is due to a tiny change in a receptor molecule on cells called TrkA, as a research team from the MDC has now discovered. The work, which appears in the journal Cell Reports, may be important for pain therapy in humans.

The life cycle of proteins

Some proteins behave in an unusual way: the older they become, the more stable they are. A research team at the MDC has now published this surprising finding in the journal Cell. Their work has traced the life cycle of thousands of proteins from synthesis to disposal. The results are relevant for diseases where there are surplus copies of certain genes.