When we drink little, we produce less urine. But how is this process regulated? An international team of scientists led by Prof. Kai Schmidt-Ott of the Max Delbrück Center for Molecular Medicine (MDC) has now shed light on how the kidneys concentrate urine.
With the Helmholtz Validation Fund, the Helmholtz Association supports projects that are particularly promising in translating research findings into viable commercial applications. Among the seven projects chosen for funding this year is a project from the MDC.
Nature study shows: Salt reduces lactic acid bacteria in the gut whichs influences immune cells responsible for autoimmune diseases and hypertension. Probiotics ameliorate the symptoms in mice.
For many obese people gaining weight is a vicious cycle. Scientists at the MDC have now uncovered a contributing factor: genetic variants linked to obesity cause the brain to produce too much of a protein called Cadm1. The result is a disruption in the regulation of body weight and changes in behavior and metabolism, as reported by Matthew Poy and his colleagues in Nature Neuroscience.
Preeclampsia, the most dangerous form of hypertension during a pregnancy is known to originate in the placenta, but the root causes remain a mystery. MDC researchers recently revealed that epigenetically regulated genes play an important role in the disease.
In recognition of his outstanding scientific achievements in kidney research, MDC researcher Prof. Kai Schmidt-Ott has been chosen by the German Society of Nephrology (DGFN) to receive the Dr. Werner Jackstädt Research Award.
In the largest transcriptome study to date, an international research team analysed the RNA of transplanted hearts and discovered a number of new risk factors for dilated cardiomyopathy and other heart conditions which could thus be recognised more easily in future.
A Berlin study of patients with early-stage colon cancer shows that DNA repair mechanisms and MACC1 gene activity helps determine prognosis and predict response to chemotherapy.
A new study in the journal Nature reveals that a small signaling molecule has the ability to cut off the blood supply to tumors. This allows the immune system’s T-cells to indirectly fight cancer.
B cells require surface molecules called B cell receptors to survive. Most tumor cells that arise from B cells seem to need them as well, but rare exceptions may escape therapies. After 15 years, scientists finally understand why.