The Landthaler lab at the MDC and their collaborators discover that a herpes virus triggers the production of over 1,000 “antisense” transcripts in the genomes of cells it infects – hinting at a new mechanism by which viruses overcome cellular defenses.
Nature study shows: Salt reduces lactic acid bacteria in the gut whichs influences immune cells responsible for autoimmune diseases and hypertension. Probiotics ameliorate the symptoms in mice.
In the largest transcriptome study to date, an international research team analysed the RNA of transplanted hearts and discovered a number of new risk factors for dilated cardiomyopathy and other heart conditions which could thus be recognised more easily in future.
Experiments increasingly rely on high-performance computing software that plays a crucial role in producing and interpreting data. Differences in software environments can cause problems when those experiments need to be reproduced – so scientists at the MDC in Berlin are helping find a solution.
In a technological tour de force, Berlin scientists have created a virtual model of an early fly embryo. Its interactive interface allows researchers to explore the blueprint that underlies development at unprecedented spatial resolution and predict which cells express which genes.
The 3D landscapes of the genome have to change all the time. Otherwise genes would not be expressed properly and physiology would be in disarray. Ana Pombo’s group is mapping this genomic regulation.