Dr. Markus Landthaler. Photo: David Ausserhofer/MDC

MDC researcher Markus Landthaler receives science prize

The cell regulates the activity of its genes in various ways. The GlaxoSmithKline  Foundation awards Dr. Markus Landthaler of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) for his innovative research about gene regulation. The systems biologist Landthaler wants to understand how proteins bind to and influence the function of the […]

Changing Architecture: A new understanding of the spatial organization of our genome

It has now been 15 years since scientists celebrated the completion of the human genome. At that point, scientists had determined the entire sequence of the genetic letters making up our DNA. It is now known that this was only an initial step in a long journey: in addition to the chemical letters, information is […]

Watching the ribosome at work

A new statistical method could help to clarify the function of unknown genes. A research team under Uwe Ohler of the Berlin Institute for Medical Systems Biology (BIMSB) at the Max Delbrück Center for Molecular Medicine (MDC) has adapted and tested a filter method from speech signal processing that makes sequencing data more interpretable. First […]

Spot on: the computational genomics summer school

“Outstanding faculty… Amazingly well organized… Great people doing very good work… Extremely interesting, even and especially for a wet-lab biologist” – the participants only had superlatives when describing the 3rd International MDC-BIMSB Summer School, taking place at the Max Delbrück Center for Molecular Medicine (MDC) from 18th until 24th of October. This time, the yearly […]

BIH funds new projects at the MDC

In scientific research the discovery of a new type of molecule that regulates the flow of information from genes to proteins has a big impact. Such new regulators are top candidates to tackle human diseases at their roots as they govern on one of the most fine-tuned cellular processes. Today’s rapid development in technology enables […]

From sequencing DNA to sequencing life

Whoever invented the term Next-Generation Sequencing (NGS) wasn’t making things easy for whoever has to name its successor – what would you call the next next generation of sequencing technology? The field continues to develop at a rapid pace, says Wei Chen, who heads the Genomics platform at the Berlin Institute for Medical Systems Biology (BIMSB). […]

Comprehensive new map helps understanding of gene regulation by microRNAs

All the cells in our bodies, be they nerve or kidney cells, blood or skin cells, carry the same genetic information. And yet they all differ considerably. This is because different genes are transcribed in each cell type. In recent years, scientists have found a new class of molecules, so-called “microRNAs,” that play a crucial […]

A metabolic worldview

The huge quantities of data generated by powerful -omics technologies are providing a much fuller understanding of biological processes, yet our knowledge remains far from comprehensive. One challenge is to combine different types of information into models of complex biochemical pathways, which then have to be integrated into even larger models to show how multiple […]