Why does it take so long for new therapies to emerge from basic research? This is a question that researchers at the MDC and beyond encounter frequently. For us it was also the starting point for a film – and food for thought about the value of basic research.
Prof. Thomas J. Jentsch knows: Results from basic research in biology sometimes can quickly become relevant for medicine. He tells us how this happened with one of his subjects of research.
Proteins perform so many vital tasks that without them, our bodies wouldn’t function. In producing these molecules cells make a remarkable number of mistakes: about one third of all newly synthesized proteins are defective. A failure to recognize and eliminate them can lead to severe diseases. A team led by Prof. Thomas Sommer at the MDC has now gained new insights into the complex process of protein quality control in the cell.
A team led by MDC researcher Annika Weber has pinpointed the efficient mechanism used by cells to label faulty proteins. The findings, which provide important insights into the functioning of protein quality control in the cell, have now been published in the journal Molecular Cell.
How does a cytostatic like cisplatin or carboplatin actually get into the cell? Scientists at the MaxDelbrück Center for Molecular Medicine in the Helmholtz Association (MDC) and the Leibniz-Institut für Molekulare Pharmakologie (FMP) in Berlin, in cooperation with a Dutch group, have now succeeded in showing that the volume-regulated anion channel VRAC is 50 % […]