In a technological tour de force, Berlin scientists have created a virtual model of an early fly embryo. Its interactive interface allows researchers to explore the blueprint that underlies development at unprecedented spatial resolution and predict which cells express which genes.
For some applications – such as in developmental biology – the genome cannot just be chopped up into tiny pieces before decoding. Instead, long read lengths of several thousand bases are needed. A recent paper in Nature shows what the PacBio sequencer at the Scientific Genomics Platform at the MDC can do.
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
The calls of new-born mice draw the attention of their mother. A group of neuronal cells in the brain stem, which coordinate exhalation and tension of muscles in the larynx is essential for this process. Without these cells, the mice are mute. These are the results of a study by a research team at the Max Delbrück Center in Berlin, which appears in the journal PNAS. The cries of human babies may well depend on similar connections, which could also be impaired in speech disorders.
A Berlin study of patients with early-stage colon cancer shows that DNA repair mechanisms and MACC1 gene activity helps determine prognosis and predict response to chemotherapy.
MRI is zooms in on a scale of life that is crucial to biomedical progress and is attracting highly talented young scientists to the intersection between physics, biology, and medicine. A report from the 8th Conference on UHF MRI at the MDC, held in June.
We have reached the half-way mark. Ute Radeklau from Berlin is the 3,000th person to be examined in the Berlin Ultrahigh Field Facility at the Max Delbrück Center for Molecular Medicine in the context of the largest German health study NAKO. It took a good hour to take a thousand MRI images of her.
Many artists use a paint brush – and so do some scientists. At the MDC, they also use a toothbrush with just one bristle. Here we reveal what this paint brush and single-bristle toothbrush activity is all about.
Prof. Holger Gerhardt of the Max Delbrück Center for Molecular Medicine (MDC) and an international team of collaborators receive a $6 million grant from the Fondation Leducq.
A new study in the journal Nature reveals that a small signaling molecule has the ability to cut off the blood supply to tumors. This allows the immune system’s T-cells to indirectly fight cancer.