Ana Pombo’s lab discovers a mechanism that silences genes but keeps them continually poised for action – even though they may never be used.
Using a single-molecule microscopy, an international team of researchers has observed live for the first time G protein-coupled receptors that perform critical functions such as mediating the biological effects of hormones. Their findings, published in the science journal Nature, could help in the search for new drugs.
Where proteins are localized within a cell is crucial to their proper function, especially in cells like neurons. It affects neuronal development and even learning and memory. A research team led by Marina Chekulaeva has for the first time systematically analyzed how this localization comes about. Their article appeared in Nature Communications.
What role do genes play in egg, milk, and nut allergies? A study published in Nature Communications, led by the Max Delbrück Center for Molecular Medicine (MDC) and Charité – Universitätsmedizin Berlin, has found five genetic risk loci that point to the importance of skin and mucous membrane barriers and the immune system in the development of food allergies.
The Max Delbrück Center for Molecular Medicine (MDC) in Berlin is participating as a research partner in the Human Cell Atlas (HCA). The Chan Zuckerberg Initiative has now announced that it will provide financial support for the HCA’s sub-project “Towards a Human Cardiac Cell Atlas.”
For many obese people gaining weight is a vicious cycle. Scientists at the MDC have now uncovered a contributing factor: genetic variants linked to obesity cause the brain to produce too much of a protein called Cadm1. The result is a disruption in the regulation of body weight and changes in behavior and metabolism, as reported by Matthew Poy and his colleagues in Nature Neuroscience.
Preeclampsia, the most dangerous form of hypertension during a pregnancy is known to originate in the placenta, but the root causes remain a mystery. MDC researchers recently revealed that epigenetically regulated genes play an important role in the disease.
On Oct. 11-13 this year the MDC is collaborating with the Charité and the Physikalisch-Technische Bundesanstalt in hosting the Second International Symposium on Functional Renal Imaging. Thoralf Niendorf, head of the Experimental Ultrahigh Field MR group at the MDC, explains what is attracting a highly interdisciplinary community to the kidney and to the MDC campus.
Biomedical research has long been way ahead of the textbooks, says Genentech Vice President Vishva Dixit. In his MDC Lecture, the researcher talked about his fascination with cell death and what it means for research into sepsis.
In the largest transcriptome study to date, an international research team analysed the RNA of transplanted hearts and discovered a number of new risk factors for dilated cardiomyopathy and other heart conditions which could thus be recognised more easily in future.