In the early 1960s Klaus Rajewsky began creating what later became, as he calls it, a “small universe”: the immunology department at the Institute for Genetics in Cologne, where he would remain for 38 years. It’s a model of how excellent science can be done against a changing landscape of ideas, technologies, and careers, producing […]
Archives for October 2016
Eating and drinking is strictly forbidden in the lab, as everyone knows. So why is milk powder often found on the shelves? Here is the explanation…
Excellent new people at the MDC: The Charité Foundation and the Einstein Foundation of Berlin are supporting three professors who will come to Berlin to collaborate with MDC groups under the framework of the BIH. The support is part of the BIH strategy to bring findings from basic research more quickly into clinical practice.
The new program “CrispRGold” program helps scientists to identify the most effective and specific RNA sequences for use genome editing experiments. It has been devised by a group of researchers headed by Prof. Klaus Rajewsky and is now described in the journal PNAS. The team has also developed a new mouse model that already carries the Cas9 protein.
Bioinformatician Roland Schwarz has been lead investigator of the new BIMSB junior research group on “Evolutionary and Cancer Genomics” since October 2016. Schwarz wants his work, particularly in the area of cancer research, to contribute towards ensuring that diseases are diagnosed earlier and treated more effectively.
Mass spectrometry metabolomics at the MDC now has a second leg to stand on: On October 1, Dr. Jennifer Kirwan took up her position as the new head of the Metabolomics Core Facility of the Berlin Institute of Health (BIH), which is situated at the MDC. Dr. Stefan Kempa, who has been in charge until now, will continue to head the Metabolomics Core Facility within BIMSB.
Protein Kinase A (PKA) is a protein that enjoys enough fame to be sketched by young biochemists listening to lectures about how it is regulated. The fundamental kinase is present throughout the body with a role in countless processes. It’s easy to think PKA is so well studied that we know everything about it, but scientists at the MDC have found a new layer of PKA regulation which was published this week in Nature Communications.
Some anticancer agents intend to disturb the function of the p97 protein complex, which is essential for survival of cancer cells. A team of researchers of the MDC has now found a way to break up the p97 complex into its subunits.
In injuries and inflammation, naked mole-rats do not develop normal hypersensitivity to temperature stimuli. This is due to a tiny change in a receptor molecule on cells called TrkA, as a research team from the MDC has now discovered. The work, which appears in the journal Cell Reports, may be important for pain therapy in humans.
Some proteins behave in an unusual way: the older they become, the more stable they are. A research team at the MDC has now published this surprising finding in the journal Cell. Their work has traced the life cycle of thousands of proteins from synthesis to disposal. The results are relevant for diseases where there are surplus copies of certain genes.