Archives for November 2015

Insights into the “dark zone”

MDC scientists publish new findings on differentiation and malignant transformation of B lymphocytes. B-cell lymphoma is one of the most common cancers derived from the lymphoid system. Lymphomagenesis is often linked to the so-called germinal center reaction. B lymphocytes represent a subgroup of the white blood cells, whose expansion after infection leads to germinal center formation. […]

Genetic cause of cleft palate

Some children are born with cleft palates and, of those children, some have an asymmetrical face and a malformed ear. A team of scientists led by Berlin-based researcher Enno Klußmann of the Max Delbrück Center for Molecular Medicine (MDC) has taken an important step towards discovering the genetic causes of this condition, known as Goldenhar […]

Neurodermatitis genes influence other allergies

There’s a typical “career” for some allergic people, and it starts very early on the skin: babies develop atopic dermatitis, food allergies may follow, then comes asthma and later on hay fever. A group of scientists led by Ingo Marenholz and Young-Ae Lee at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association […]

Sharper, wider, deeper, brighter

Just when you thought you’d seen it all… the Advanced Light Microscopy Facility is expanding its “scope” with new instruments, methods, and projects The duet between basic research and medicine has been a Leitmotif of Berliner culture since long before the establishment of the BIH, the ECRC, or the MDC – and predates even Oskar […]

Uptake mechanisms of cytostatics discovered

How does a cytostatic like cisplatin or carboplatin actually get into the cell? Scientists at the MaxDelbrück Center for Molecular Medicine in the Helmholtz Association (MDC) and the Leibniz-Institut für Molekulare Pharmakologie (FMP) in Berlin, in cooperation with a Dutch group, have now succeeded in showing that the volume-regulated anion channel VRAC is 50 % […]

Translational research yields new approaches to treatment for rare diseases

Rare diseases – sometimes referred to as “orphan diseases” – get left behind in the development of new treatments because of their low prevalence: because patient numbers are small, clinical studies are difficult to conduct and the pharmaceutical industry has no commercial interest in the issue. What can help here is close cooperation between publicly […]

Spot on: the computational genomics summer school

“Outstanding faculty… Amazingly well organized… Great people doing very good work… Extremely interesting, even and especially for a wet-lab biologist” – the participants only had superlatives when describing the 3rd International MDC-BIMSB Summer School, taking place at the Max Delbrück Center for Molecular Medicine (MDC) from 18th until 24th of October. This time, the yearly […]